Living With Rheumatoid Arthritis


Rheumatoid arthritis is an autoimmune and chronic inflammatory disorder that occurs when the immune system attacks the body’s own healthy tissues. Early rheumatoid arthritis mainly attacks the smaller joints first, particularly the joints that attached the fingers to the hands and the toes to the feet. As the disease progresses, the inflammation starts to spread to the wrists, knees, ankles, elbows, hips and shoulders.


In most rheumatoid arthritis, the symptoms affect the same joints on both sides of the body. Rheumatoid arthritis is different from osteoarthritis. Osteoarthritis occurs when the joints go through wear-and-tear damages. Rheumatoid arthritis happens when the immune system mistakenly sends antibodies to attack the synovium – the lining of the membranes that surround the joints. Attack on the synovium results in inflammation which leads to  thickening of the synovium, and  then eventually destroys the cartilage and bone within the affected joint. The tendons and ligaments that hold the joint together will be weakened and stretched and gradually, making the joint lose its shape and alignment.


Signs and symptoms of rheumatoid arthritis may include:

a) tender, warm and swollen joints

b) joint stiffness that usually worsen in the mornings and after inactivity

c) fatigue, fever and loss of appetite


The symptoms may vary in severity and can come and go. The periods of heightened immunity called flares alternating with periods of relative remission when the pain and swelling subside. Over time, rheumatoid arthritis can cause the joint to deform and shift out of place.

In rheumatoid arthritis, when the immune system attacks the healthy joint tissues, it leads to joint inflammation. The damaged cartilage will be removed. In arthritic individuals, they will experience more joint inflammation than repair. Most conventional therapies aim at suppressing the immune system non-specifically and usually are related to side effects including infections.

Making Moves With Native Type II Collagen in Joint Health

Collagen is becoming increasingly popular in joint health. It is the main component that provides structural support throughout the body. Out of the 28 types of collagen identified, the main structural protein in cartilage is type II collagen. Scientific evidence has demonstrated the effectiveness of undenatured type II collagen in supporting joint health. Undenatured type II collagen means type II collagen in its native form. It works via oral tolerance, an immune-mediated process. Oral tolerance is an immune process that allows the body to recognize proteins, in this case of collagen type II found in the joint  to prevent an over-active immune response.

UC-II - The Revolutionary Supplement In RA

Researchers believe that ingested UC-II® undenatured type II collagen is transported across the gut walls to the underlying immune cells in the Peyer’s patches, where most immune responses are induced here in the digestive tract. It activates a type of immune cells known as naïve T cells to become T regulatory cells that will specifically target type II collagen in the joint cartilage. The ingestion of UC-II® undenatured type II collagen trains the immune system to recognize type II collagen as a protein that occurs naturally in the body. This suppresses the body’s own immune system to launch an attack on its own type II collagen. This mechanism will prevent the potentially dangerous over-reactive immune system, to keep the immune system in balance. This results in lesser inflammation and pain in rheumatoid arthritis patients.


UC-II® undenatured type II collagen was demonstrated to increase the immune system components that favour the anti-inflammatory pathways and may trigger the natural rebuilding of the joint cartilage in rheumatoid arthritis. It only needs a small amount of undenatured type II collagen (40mg/day) to get our own immune system to participate to repair the joint cartilage.  It is different from hydrolyzed collagen which needs to be consumed between 5000mg to 10000mg a day to reduce joint pain.


In conclusion, UC-II® undenatured type II collagen is proven to exert its joint health benefits through oral tolerance via the anti-inflammatory and cartilage protective pathways to reduce pain and inflammation, as well as  preventing  self-damage to own joint cartilage. Keep in mind that not all collagens are created equal, especially on prevention and treatment of auto-immune disease such as rheumatoid arthritis. Hydrolyzed collagen is not indicated for such diseases.

Kordel’s Jflexi - Powered By UC-II®

Kordel’s Jflexi is made from UC-II undenatured type II collagen. It  is taken once or twice a day, depending on body weight to reduce joint pain, as well as improving joint flexibility and mobility. It is derived from chicken sternum cartilage and is suitable for individuals who are allergic to seafood. It is suitable to be taken by diabetics

because it does not affect the body’s blood sugar control. It is an effective supplement for rheumatoid arthritis, convenient to be taken at a low dose.This will help to  reduce pill fatigue that happens when a person has to take too many medications.


In short, if you encounter any pain and discomforts on your joints, regardless if it is RA or OA (osteoarthritis), just grab a box  of Kordel’s J-Flexi. You will be free to move again in the shortest time possible !

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