Probiotic, The Ultimate Solution

Stress in Mothers, Eczema in babies

There are many things you have to consider and prepare for when pregnant, and your gut should be one of them. A strong and healthy gut is vital for both mom and baby. If you have a poor diet, drink soda, take antibiotics or have high-stress levels while pregnant, it can take a toll on your gut and your baby’s immunity. If you are taking a probiotic while pregnant, it could be essential to the health of you and your baby.

An expectant mother’s mental well-being can affect her baby after birth. A recent review published three years ago revealed that mothers who experienced stress before, during and soon after pregnancy increase the risks of eczema in their children (Chan et al 2018). Stress in pregnant mothers include prenatal or postnatal depression, prenatal anxiety, maternal stress during pregnancy, adverse life events, distress and job strain during pregnancy. 

Eczema, recognized by red, itchy patches of skin, is a precursor to a variety of other conditions such as food allergies and asthma, so reducing or preventing it is very important. We know that differences in a baby’s microbiome link to increased allergy risks, and research is supporting the use of probiotics to prevent eczema.

Eczema can affect a child’s health and quality of life. Physical comfort, sleep, social interactions and self-image can all be affected, even a simple task such as handwashing. Handwashing is one of the best ways to prevent the spread of COVID-19 especially to toddler or children in the nursery. However, when a toddler has a skin condition such as eczema, washing hands frequently can lead to dry and cracked skin, itchiness, pain and possibly an infection.

Maternal Stress Is Linked With Eczema In Babies

A new study conducted by the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, revealed that women who are under stress before conceiving can increase the risk of eczema in their newborns.  Maternal stress can release certain hormones that can impact the baby’s immune response. This could lead to an increased risk in eczema.  In this survey, women were asked to report how stressful they were in their daily lives. More than one in six women reported that their stress level has taken its toll on their health. The risk of their infants developing atopic eczema at the age of 12 months is 20% higher than other participants in the survey (El-Heis et al 2017). 

Lactobacillus rhamnosus HN001

One Solution, Two Problems

423 women were recruited in a 2 years trial. 212 women were given a unique strain of probiotic known as Lactobacillus rhamnosus HN001™ while 211 were placed in the placebo group. It was demonstrated that mothers taking L. rhamnosus HN001™ reported a significantly lower depression and anxiety score. (Slykerman et al 2017). L. rhamnosus HN001™ is proven to reduce pregnancy stress and its benefits are extended to the infants with lower prevalence in eczema development (Wickens et al 2018).

Lactobacillus rhamnosus HN001™

Starts Early Life Gut Microbiota

Human studies have shown that supplementing with probiotics during pregnancy can improve the new-born’s immunity and reduce the risk of preterm birth. Lactobacillus rhamnosus HN001™ is a well-documented strain of probiotic that has demonstrated an impressive efficacy in immunity. The combination of L. rhamnosus HN001™ and L. acidophilus NCFM® helps to develop an infant microflora and immune functions, thus, reducing the development of allergies and eczema. This combination helps expecting mothers to support their babies’ immunity as well as their own by reducing stress in pregnancy (Dekker 2009).

Lactobacillus rhamnosus HN001™ is the first strain of probiotic that is proven to be safe and effective in infants and pregnant mothers. A double-blind, randomized placebo controlled involving 316 mothers and their infants showed the prevalence if eczema was 49% lower than the placebo group. At 4 years, the relative risk of rhinitis and red eyes was found to be 62% lower in the probiotic group. The benefits were still present at 6 years of age, when the cumulative prevalence of eczema was 44% lower in the probiotic group. The significant benefits of this strain of probiotic are observed during the first 2 years of life with a prolonged effect over 11 years. It has a unique long-term benefit in promoting a balanced immune health. L. rhamnosus HN001™ has been extensively studied across all life stages from early infancy through elderly years, and in pregnant and lactating women. Most notable is its ability to impact the immune system and long-term safety profile in infants and children to support early life immune homeostasis (Wickens et al 2013).

Lactobacillus rhamnosus HN001™

Optimizes Sugar Control In Pregnancy

Pregnancy changes the way a woman’s body utilises glucose. This can make diabetes worse or leads to gestational diabetes. Gestational diabetes is a condition marked by a high blood sugar level during pregnancy. The elevated blood glucose can sometimes cause delivery issues, health problems in babies or developing type 2 diabetes after given birth. Pregnant women or recently pregnant women who are older, overweight, and have pre-existing medical conditions such as hypertension and diabetes seem to have an increased risk of developing severe COVID-19. When pregnant women develop severe disease, they also seem to more often require care in intensive care units than non-pregnant women of reproductive age. Being pregnant, in general, means her immune system is more compromised and uncontrolled blood sugar will further complicate the matter.

Gestational diabetes not only affects the babies’ development but also increases the vulnerability to emotional upheaval such as depression, anxiety and stress among pregnant women (Lee et al 2019). The transition to motherhood is already a major life-changing event and is also a stressful condition when it is associated with diabetes. Studies have shown that the prevalence of depressive symptoms, anxiety and stress can be as high as 60% in women with gestational diabetes (Egan et al 2017). Undiagnosed and untreated antenatal depressive and anxiety symptoms in women with gestational diabetes could lead to postpartum depression and anxiety.

Pregnant mothers who start early supplementation of Lactobacillus rhamnosus HN001™ strain of probiotics have shown a reduced risk of gestational diabetes. Lactobacillus rhamnosus HN001™ also helped to prevent future episodes of gestational diabetes. The prevalence of gestational diabetes has dropped to 0% in the treatment group who has a previous history of gestational diabetes. The prevalence in the placebo group was as high as 87% (Tingmin Koe 2019) .

Kordel’s Protect Early Life

The Pre- and Post-Natal Probiotic

Kordel’s Protect EarlyLife is a combination of L. acidophilus NCFM® and Lactobacillus rhamnosus HN001™. L. rhamnosus HN001™ is a special strain of probiotics which has been proven to reduce stress and anxiety in pregnant women and its benefits are extended to the infants with lower prevalence in eczema development. Early supplementation of Lactobacillus rhamnosus HN001™ may reduce the prevalence of gestational diabetes mellitus. Kordel’s Protect EarlyLife, the one-of-the kind probiotic that is proven safe to mothers and her babies while providing a wide spectrum of benefits to both mother and her newborn.

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References:

1. Chan et al. The association between maternal stress and childhood eczema: A systemic review. Int J Environ Res Public Helath 2018 Mar;15(3):395.

2. El-Heis et al. Maternal stress and pyschological distress preconception: Association with offspring atopic eczema at age 12 months old. Clinical & Experimental Allergy. 20 February 2017. https://doi.org/10.1111/cea.12910

3. Slykerman et al. Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: A randomised double-blind placebo-controlled trial. Ebiomedicine 24(2017) 159-165.

4. Wickens et al. Effefcts of Lactobacillus rhamnosus HN001 in early life on the cummulative prevalence of allergic disease to 11 years. Pediatr Allergy Immunol. 2018 17. doi: 101111/pai.12982.

5. Dekker et al. Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacteriu, animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal 19(2009) 149-150.

6. Wickens et al. Early supplementation with Lactobacillus rhamnosus HN 001 reduces eczema prevalence  to 6 years: does it also reduce actopic sensitization? Clin Exp Allergy. 2013 Sep;43(9):1048-57

7. Lee et al. Prevalence and factors associated with depressive, anxiety and stress symptoms among those with gestational diabetes mellitus in tertiary care centres in Malaysia: a cross-sectional study. BMC Pregnancy and Childbirth (2019)19:367. https://doi.org/10.1186/s12884-019-2519-9.

8. Egan et al. Diabetes in pregnancy: worse medical outcomes in type 1 diabetes but worse psychological outcomes in gestational diabetes. QJM: Int J Med. 2017;110(11):721-7.

9. Tingmin Koe. Mother-baby link: Probiotic intake during pregnancy improves infant immunity by reducing risk factors. Probiota Asia 2019.